Payers’ Hands Are Still Tied With Oncology Combination Regimens

Posted by Nicolle Hamilton on May 23, 2019 10:11:35 AM

Lawrence Lee co-wrote this blog post with Nicolle Hamilton.  

The oncology pipeline is rich with potential combination regimens across both liquid and solid tumor types. Several manufacturers are developing or marketing PD-1/PD-L1 checkpoint inhibitors as a “backbone” for their combination regimen portfolio. Although there are only a few currently marketed regimens with multiple targeted agents (such as Opdivo-Yervoy in ovarian cancer, Tafinlar-Mekinist in metastatic melanoma, and several combos in multiple myeloma), combination approaches may become the standard of care for many tumor types. Indeed, these novel-novel approaches can yield compelling clinical outcomes. For example, Opdivo-Yervoy reduced progression risk by 58% vs. Yervoy alone in melanoma.


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How to Pay for Transformative Cell and Gene Therapies

Posted by Bernadette Bourjolly on Oct 13, 2017 8:00:00 AM

Malik Kaman co-wrote this blog post with Bernadette Bourjolly. 

After two decades of failures and setbacks, it’s an exciting time in the field of cell and gene therapies as we witness pioneering advances in a wide range of indications in areas including blood cancers, immunodeficiency and ophthalmology. While cell and gene therapies represent a potential paradigm shift for the treatment of cancer and rare genetic disorders, funding and reimbursement of these unconventional therapies pose major challenges. 


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ESMO 2017: Examining New Models to Define, Measure and Pay for Value

Posted by Richard Secker-Johnson on Sep 27, 2017 11:08:36 AM

Can true value-based pricing ever be a reality in Europe? If the answer is no, we may well be headed towards a price/access “crisis” as rising oncology costs continue to outstrip country healthcare budgets. If the answer is yes, it certainly seems like there’s still a long way to go.


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